(Am J Ophthalmol 2009;148:459-465. (C) 2009 by Elsevier Inc. All rights reserved.)”
“New series of substituted glutamine 5a-1 and glutamic acid diamides, diureide and dihydrazide 7a-e were synthesized from parent glutamic acid compound 3 and evaluated for their cytotoxic activity against tumor cell line PC3 (prostate cancer cell line). Most of the tested compounds exploited potent growth inhibitory activity with IC50 values ranging 0.034-3.97 mu M.

Particularly, compounds 5a, 3, 5j, 5b, 7c, 7e, 5l, and 5k exhibited superior potency (IC50=0.034, 0.04, 0.05, 0.074, 0.25, 0.4, 0.49, 0.522 mu m, respectively) to the reference drug Doxorubicin (IC50=0.63 mu M), while compound 7b showed IC50, 0.71 mu M, comparable to that of Doxorubicin. In summary, the newly synthesized compounds provided promising new lead

for the future design and development of glutamine selleck chemical and glutamic acid derivatives as novel antitumor agents. The quantitative structure activity relationship (QSAR) study was applied to find a mathematical correlation between the structures of compounds and their activity against PC3 cell line expressed as IC50 values.”
“Objective To determine the relationship between the timing of chemistry and timing of prenatal diagnosis and CA4P pregnancy termination in pregnancies with chromosomal abnormalities.\n\nMethod Singleton pregnancies with chromosomal abnormalities from 2005 to 2009 were identified. Records were reviewed to identify timing of chemistry, nuchal translucency (NT), prenatal diagnosis and pregnancy termination. Mann-Whitney

U and Fisher’s exact test were used for statistical analysis.\n\nResults A total of 110 pregnancies were included. Seventy-eight had biochemistry performed at the time of NT and 32 had biochemistry a median of 9 days prior. Aneuploidy risks were similar between the two groups. Although the timing of NT was similar, those having biochemistry before NT had prenatal diagnosis and pregnancy SN-38 purchase termination at significantly earlier gestational ages. Those with early biochemistry were more likely to have chorionic villus sampling (CVS) (69% vs 37%; p = 0.003) compared to those who had biochemistry at the time of NT.\n\nConclusion There was a strong correlation between the timing of biochemistry and prenatal diagnosis and pregnancy termination. Copyright (C) 2010 John Wiley & Sons, Ltd.”
“Aseptic meningitis related to hydrogel-coated coils is a known complication, but it is extremely rare after platinum bare coil aseptic meningitis. Here we report the development of aseptic meningitis causing brain stem and cerebellar infarct in a patient with a giant aneurysm treated with bare platinum coils. We conclude that aneurysm size is an important factor affecting the occurrence of aseptic meningitis associated with stroke.”
“Objective: In multiple endocrine neoplasia type 1, the main risk factor for metastases is pancreatic turnout size.