Their predictive performance can be characterized in two complementary ways: discrimination, the ability to distinguish between occupied and unoccupied sites, and calibration, the extent to which a model correctly predicts conditional probability of presence. The most common measures of model performance,

such as the area under the receiver operating characteristic curve (AUC), measure only discrimination. In contrast, we introduce a new tool for measuring model calibration: the presence-only WH-4-023 calibration plot, or POC plot. This tool relies on presence-only evaluation data, which are more widely available than presence-absence evaluation data, to determine whether predictions are proportional to conditional probability of presence. We generalize the predicted/expected curves of Hirzel et al. to produce a presence-only analogue of traditional (presence-absence) calibration curves. POC plots facilitate visual exploration of model calibration, and can be

used to recalibrate badly calibrated models. We demonstrate HSP990 inhibitor their use by recalibrating models made by the DOMAIN modeling method on a comprehensive set of 226 species from six regions of the world, significantly improving DOMAIN’s predictive performance.”
“Phenytoin (PHT), an anticonvulsant agent, widely used for the treatment of epilepsy has been reported to exhibit toxic side effects. The present study investigated the protective effects of kolaviron and vitamin E on hematotoxicity and neurotoxicity induced by phenytoin, in prepubertal

male rats. The animals were treated with PHT (75 mg/kg) separately or in combination with either kolaviron (200 mg/kg) or vitamin E (500 mg/kg) for 14 days. Phenytoin treatment significantly decreased the hemoglobin, white blood cells, lymphocytes and mean corpuscular volume levels without affecting red blood cell, packed cell volume, neutrophils, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration when compared with the control rats. There was a significant increase in lipid peroxidation and hydrogen peroxide levels with marked depletion in antioxidant status in brains of PHT-treated rats when PHA-848125 nmr compared with the control. Although PHT treatment had no effect on the granular layer, widest diameter of Purkinje cells and Purkinje layer of the cerebellum, it significantly reduced its molecular layer and the density of Purkinje cell. Administration of PHT significantly reduced the densities of the granule cells of the dentate gyrus and the pyramidal neurons of the cornu ammonis of hippocampus proper. Co-treatment with kolaviron and vitamin E effectively reversed the PHT-mediated alterations in the hematology, brain antioxidant status and histomorphometry when compared to PHT only.